Billings-Gagliardi, Susan 1R01 NS42271-01A ES Blastocyst - Injected Shiverer Mice These movie clips show the motor behavior of the three mice whose brains are illustrated in Figures 5 and 6 (pp. 30-31, and APPENDIX plates). You can view them as QuickTime or Media Player Movies. A shiverer mouse for comparison Quick Time Media Player Essentially Rescued (Figs. 5 and 6) This mouse has minimal tremor limited to the base of the tail and no gait ataxia. (Tremor is most obvious as the animal begins locomotion.) Quick Time Media Player Intermediate (Figs. 5 and 6) This mouse has mild tremor involving the hindquarters as well as tail base. Although gait is somewhat ataxic, tail flinging is minimal. Quick Time Media Player Minimally Rescued (Figs. 5 and 6) This mouse has significant tremor affecting much of its body and gait ataxia, which involves uneven strides, lateral rolling of the hindquarters, and some flinging of the tail. Behaviorally this mouse is similar to shiverer, although subtle differences were identified by an experienced observer (S.B.-G.). Quick Time Media Player Essentially and Minimally Rescued Mice Together Quick Time Media Player For further information or technical assistance contact Susan Billings-Gagliardi Department of Cell Biology, University of Massachusetts Medical School 55 Lake Avenue North, Worcester, MA 01655

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